Bruce J Brew Selected Research

Kynurenine

6/2020	Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
1/2019	Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau.
1/2017	Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression.
1/2016	Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis.
1/2015	Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.
12/2014	Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.
1/2014	Involvement of the kynurenine pathway in human glioma pathophysiology.
1/2013	Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.
1/2013	Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages.
11/2012	The kynurenine pathway in brain tumor pathogenesis.

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Bruce J Brew Research Topics

Disease

15	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2002
14	HIV Infections (HIV Infection) 01/2018 - 03/2003
12	Infections 01/2022 - 05/2000
12	AIDS Dementia Complex 06/2010 - 01/2003
11	Dementia (Dementias) 01/2022 - 09/2004
11	Neurocognitive Disorders (Clerambault Syndrome) 01/2021 - 01/2010
10	Neuroinflammatory Diseases 06/2020 - 07/2005
10	Multiple Sclerosis 01/2017 - 01/2007
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 03/2003
8	Acquired Immunodeficiency Syndrome (AIDS) 12/2018 - 07/2003
7	Inflammation (Inflammations) 05/2020 - 12/2009
6	Disease Progression 01/2022 - 01/2011
5	Cognitive Dysfunction 01/2020 - 12/2006
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 01/2005
3	Opportunistic Infections (Opportunistic Infection) 08/2014 - 12/2009
3	Neoplasms (Cancer) 01/2014 - 11/2007
3	Polyneuropathies (Polyneuropathy) 01/2013 - 05/2003
3	Pain (Aches) 01/2013 - 12/2006
3	Brain Diseases (Brain Disorder) 01/2013 - 05/2008
3	Brain Injuries (Brain Injury) 06/2010 - 03/2007
2	Central Nervous System Infections (Central Nervous System Infection) 01/2022 - 06/2010
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/2020 - 12/2014
2	Lymphoma (Lymphomas) 02/2016 - 06/2004
2	Progressive Multifocal Leukoencephalopathy 01/2016 - 08/2013
2	Brain Neoplasms (Brain Tumor) 01/2014 - 11/2012
2	Amyloid Plaque 01/2013 - 01/2002
2	Parkinson Disease (Parkinson's Disease) 10/2010 - 01/2010
1	Neurobehavioral Manifestations 01/2022
1	Neuromyelitis Optica (Devic's Disease) 05/2020
1	Headache (Headaches) 01/2018
1	Meningitis 01/2018
1	Migraine Disorders (Migraine) 01/2018
1	Substance-Related Disorders (Drug Abuse) 01/2018
1	Migraine with Aura (Familial Hemiplegic Migraine) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	B-Cell Leukemia (Leukemia, B Cell) 01/2017
1	Insulin Resistance 01/2016
1	Nervous System Diseases (Neurological Disorders) 12/2014
1	Glioma (Gliomas) 01/2014

Drug/Important Bio-Agent (IBA)

24	KynurenineIBA 06/2020 - 01/2002
19	Quinolinic AcidIBA 01/2021 - 01/2002
13	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2007
8	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2000
8	Tryptophan (L-Tryptophan)FDA Link 01/2017 - 01/2003
7	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2005
7	NeurotoxinsIBA 12/2014 - 01/2003
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 12/2009
4	NeopterinIBA 01/2019 - 03/2007
4	EnzymesIBA 01/2014 - 11/2007
3	Indicators and Reagents (Reagents)IBA 01/2018 - 08/2005
3	Pharmaceutical PreparationsIBA 01/2016 - 03/2007
3	NAD (NADH)IBA 01/2014 - 01/2009
3	Amyloid beta-PeptidesIBA 06/2013 - 01/2002
2	Glutamic Acid (Glutamate)FDA Link 01/2019 - 01/2018
2	Choline (Choline Chloride)IBA 01/2019 - 01/2018
2	N-acetylaspartate (N-acetyl aspartate)IBA 01/2019 - 01/2018
2	CreatineIBA 01/2019 - 01/2018
2	Inositol (Myoinositol)IBA 01/2019 - 01/2018
2	Glutamine (L-Glutamine)FDA Link 01/2019 - 01/2018
2	Protons (Proton)IBA 01/2018 - 06/2013
2	AntibodiesIBA 01/2016 - 06/2010
2	Biological ProductsIBA 01/2016 - 04/2011
2	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 08/2009
2	Antiviral Agents (Antivirals)IBA 09/2014 - 03/2007
2	Carboxy-LyasesIBA 01/2014 - 11/2012
2	Interferon-gamma (Interferon, gamma)IBA 01/2014 - 06/2013
2	Capsaicin (Zostrix)FDA Link 01/2013 - 02/2012
2	Stavudine (Zerit)FDA LinkGeneric 01/2013 - 05/2003
2	CytokinesIBA 12/2009 - 03/2003
2	HIV Core Protein p24IBA 12/2009 - 09/2007
2	Messenger RNA (mRNA)IBA 01/2007 - 03/2003
2	ChemokinesIBA 01/2007 - 03/2003
1	CreatinineIBA 01/2022
1	Mixed Function Oxygenases (Monooxygenases)IBA 06/2020
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 06/2020
1	AutoantibodiesIBA 05/2020
1	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2020
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019
1	MicroRNAs (MicroRNA)IBA 12/2018
1	Combined Oral ContraceptivesIBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 01/2018
1	Contraceptive Agents (Contraceptives)IBA 01/2018
1	Estrogens (Estrogen)FDA Link 01/2018
1	NucleotidesIBA 01/2018
1	Progestins (Progestagens)IBA 01/2018
1	Tryptamines (Triptans)IBA 01/2018
1	Desogestrel FDA LinkGeneric 01/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	Maraviroc FDA Link 02/2016
1	CCR ReceptorsIBA 02/2016
1	IgA receptor (protein B)IBA 02/2016
1	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA 01/2014
1	kynurenine-oxoglutarate transaminaseIBA 01/2014

Therapy/Procedure

22	Highly Active Antiretroviral Therapy (HAART) 01/2021 - 02/2002
15	Therapeutics 01/2021 - 09/2004
1	Art Therapy 01/2021
1	Hormonal Contraception 01/2018
1	Mediterranean Diet 01/2018
1	Activities of Daily Living (ADL) 10/2017